Targit information

Targeted intra-operative radiotherapy (TARGIT) using Intrabeam is an elegant approach of partial breast irradiation for an expanding number of solid tumours including breast cancer, rectal cancer, vulval and skin cancer, brain tumours and bone metastasis. It delivers a precise and timely dose of intraoperative radiotherapy accurately to the tumour.

Historical Perspective

A Photon Radiosurgery System (PRS) was introduced at The Royal Free Hospital in 1995 to assess its role in the treatment of solitary brain metastases. The tip of the probe was placed into the tumour, using standard stereotactic techniques, allowing for the delivery of a prescribed therapeutic radiation dose directly into the centre of the metastasis. A dose of 10–20 Gy was prescribed to the margin of the treatment volume defined as the volume seen on CT scan with a 2 mm margin. Between April 1995 and April 1997 eleven patients with cerebral metastases were treated with the PRS (Porter et al. 1998 ). Subsequently, the system was trialed for the first time in treatment of primary breast cancer at the University College London after the design and development of polymer applicators of various diameters to insert into the tumour cavity after resection (Vaidya et al. 1999 ).